961.The maintenance dose of a drug with a clearance of 1000mL/min, V of D of 50 L, half life of 34 minutes and desired concentration of 2mg/mL and extraction ratio of 1.5 is
A.Not able to be calculated from the information given
B.60 g/h
C.2 g/min
D.2000 mg/h
E.6 mg /min

962.All of the following demonstrate flow-dependent elimination except
A.Lignocaine
B.Morphine
C.Phenytoin
D.Propranolol
E.Verapamil

963.Regarding elimination kinetics all of the following are true except
A.in 1storder kinetics, the rate of elimination is proportional to the drug concentration
B.ETOH displays dose dependant kinetics
C.Zero order kinetics involves a constant rate of elimination
D.Most drugs display 1storder kinetics
E.Phenytoin may display zero order kinetics

964.Which is false
A.Half-life is inversely proportional to volume of distribution
B.Half-life is constant in first order clearance
C.╬▒half-life is usually shorter than ╬▓ half life
D.half-life is not constant in zero order kinetics
E.half-life is determined by the molecular weight of a drug

965.Which is not a determinant of the volume of distribution
A.pKa of the drug
B.degree of plasma proteinbinding
C.dose given
D.fat parturition co-efficient
E.degree of tissue binding

966.Which of the following has zero order elimination
A.Warfarin
B.Phenytoin
C.Paracetamol
D.Digoxin
E.None of the above

967.Following the cessation ofdrug therapy, how many half lives does it takefor 97% of the drug to be eliminated?
A.1
B.3
C.5
D.7
E.9

968.All of the following influence clearance except
A.Dose
B.Blood flow
C.Intrinsic liver and / or renal function
D.Protein binding
E.1storder elimination

969.Volume of distribution
A.Relates dose to clearance
B.Is not an apparent volume
C.If high, implies increased concentration of drug extravascularly
D.If high, implies increased plasma protein binding
E.If high, implies easier clearance of the drug by haemodialysis

970.All of the following alter the volume of distribution except
A.Cardiac failure
B.Clearance
C.Age
D.Burns
E.Pleural effusion

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