891.On administration of an anti-histamine, which of the following effects are caused by receptors other than histamine receptors
A.Sedation
B.Postural hypotension
C.Nausea and vomiting
D.LA
E.All of the above

892.Suxamethonium will –which is incorrect
A.increase HR
B.decrease HR
C.cross BBB

893.Thiopentone
A.causes intraarterial thombosis
B.less fat soluble than other IV induction agents

894. Anticholinesterases antagonize
A.Suxamethonium
B.tubocurarine

895.Which statement regarding hepatic enzyme induction is INCORRECT
A.Induction takes 7-10 days to reach maximum
B.Inhibition occurs more rapidly than induction
C.Induction ceases within a few days of withdrawal of drug
D.Suicide inhibitors are metabolized to products which inhibit the metabolizing enzymes
E.Induction is associated with an increase in hepatic smooth ER

896.One mechanism of transmembrane signaling uses a G protein to generate an intracellular second messenger. The following are second messengers except
A.cGMP
B.Ca2+
C.cAMP
D.adenylyl cyclase
E.phosphoinositides

897.The following drugs exhibit flow-dependent elimination (i.e.‘high extraction drugs)
A.Lignocaine
B.Morphine
C.Phenytoin
D.Propranolol
E.Verapamil

898.Nitrous oxide, steroids, vitamin D and thyroid hormone act on receptors via
A.Intracellular receptors e.g.response elements
B.Ligand regulated transmembrane enzymes
C.Ligand gated channels
D.G proteins
E.2ndmessengers e.g.cAMP

899.Regarding elimination kinetics which is false
A.In 1storder kinetics, the rate of elimination is directly proportional to drug concentration
B.Ethanol displays dose dependent kinetics
C.In zero order kinetics the rate of elimination is constant
D.Most drugs display 1storder kinetics
E.Phenytoin can display zero order kinetics

900.Which of the following is not an inducer of hepatic drug-metabolising enzymes
A.Cigarette smoke
B.Phenytoin
C.Charcoal broiled beef
D.Chloramphenicol
E.Spironolactone

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