911.The following act by binding transmembrane enzyme receptors except
A.Insulin
B.PDGF
C.EGF
D.ANF
E.Thyroid hormone

912.Which of the following act via cytokine receptors
A.Growth hormone
B.EPO
C.IFN
D.All of the above
E.None of the above

913.The following use cAMP 2ndmessenger except
A.Catecholamines via α1 receptor
B.Catecholamines via β receptor
C.Glucagons
D.FSH
E.Vasopressin (V2 receptor)

914.The following have serpentine receptors except
A.α2adrenergic amines
B.ACh muscarinic
C.ACh nicotinic
D.Β adrenergic amines
E.Glucagons

915.Clinical effectiveness of a drug depends most on
A.Potency
B.Maximal efficacy
C.KD
D.Quantal dose-effect curve
E.None of the above

916.Therapeutic index is
A.EC50:TD50
B.KD:TD50
C.ED50:TD50
D.Emax:TD50
E.KD:Emax

917.In Zero-order kinetics
A.Rate elimination is proportional to concentration
B.Clearance can be calculated from AUC
C.Clearance does not depend on drug concentration
D.Clearance is always constant
E.Drugs exhibit capacity limited elimination

918.Bioavailability is not reduced by
A.first pass metabolism
B.P glycoprotein
C.Ionization of drug
D.Drugs highly extracted by liver
E.Enteric coating

919.Drugs highly extracted from the liver include all except
A.Isoniazid
B.Morphine
C.Propranolol
D.Verapamil
E.Diazepam

920.Drugs poorly extracted from the liver include all except
A.TCA
B.Chlorpropramide
C.Phenytoin
D.Theophylline
E.Warfarin

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