661.Propranolol
A.Is a highly selective β blocker
B.Is poorly lipid soluble
C.Has sodium channel blocking action
D.Has intrinsic sympathomimeticactivity
E.Has an oral bioavailability of > 50%
662.Effects of β blockers include
A.Stimulation of aqueous humour production
B.Inhibition of bronchial smooth muscle spasm
C.Stimulation of lipolysis via sympathetics
D.Stimulation of the release of renin
E.Inhibition of glycogenolysis in the liver
663.Regarding phenytoin
A.Oral bioavailability is variable
B.Binds poorly with plasma proteins
C.Metabolism is enhanced in presence of inducers of liver metabolism
D.Elimination kinetics shift from first order to zero order at moderate to high dose
E.Half life varies from 12-36 hours
664.Drugs with no significant effect on anticoagulant therapy include
A.Amiodarone
B.Disulfiram
C.Fluconazole
D.Benzodiazepines
E.Metronidazole
665.ACE inhibitors
A.Decrease levels of bradykinin
B.Cause hyperkalaemia less often in patients with diabetes
C.Are contraindicated in patients on NSAIDS
D.Decrease glomerular efferent arteriolar resistance
E.Lead to decreased PG synthesis
666.coronary artery dilation occurs with
A.adenosine
B.high K
C.propranolol
D.enalapril
E.none of the above
667.which doesn’t prolong the refractory period in normal cells
A.Amiodarone
B.lignocaine
C.sotalol
D.quinine
E.procainamide
668.regarding adenosine
A.its receptors are ion channels
B.it increases AV nodal conduction
C.it enhances K conductance
D.it is the drug of choice in VF
E.half life = 2 minutes
669.which is not true of diuretics
A.loop diuretics can be used to treat hypercalcaemia
B.frusemide is used in the prophylaxis of acute mountain sickness
C.cirrhotic oedema responds to spironolactone
D.they may enhance the efficacy of ACE inhibitors
E.hydrochlorothiazide is useful in diabetes insipidus
670.Which is not the correct site of action
A.Spironolactone = collecting duct
B.Triamterene = ascending loop of Henle
C.Thiazides = proximal part of distal tubule
D.Frusemide = proximal tubule
E.Acetazolamide = collecting tubule