651.Adverse reaction of frusemide includes all except
A.Low K metabolic acidosis
B.High Ca
C.Low Mg
D.Gout
E.Ototoxicity
652.The following is true for adrenaline except
A.It acts via G-proteins
B.αreceptor stimulation results in decreased cAMP production
C.it may be administered via inhalation, orally or parenterally
D.it has no active metabolites
E.in cardiac arrest it facilitates CPR via peripheral vasoconstriction
653.Heparin
A.Inhibits clotting by decreasing AT III effects
B.Oral bioavailability is 20-30%
C.Is low plasma protein bound
D.Molecular weight ranges from 3000 –60 000
E.Binds to AT III causing a conformational change
654.Aspirin
A.is hydrolysed to acetone and salicylate
B.exhibits first order kinestics with elimination in low doses
C.is mostly conjugated by the liver and excreted in the bile
D.reversibly blocks the COX enzyme
E.causes an immediate doubling of bleeding time
655.Amiodarone
A.effects Na, K channels but not Ca channels
B.has antianginal effects
C.has a short half life
D.increases peripheral resistance
E.has little effect on the lung
656.GTN has its major effects on angina via
A.Reducing coronary vasospasm
B.Reducing RAAS effect
C.Reducing afterload and preload
D.Coronary vasodilation
E.Systemic vasoconstriction
657.Warfarin
A.Is 90% bioavailable
B.Inactivates Vit K
C.Can cause venous thrombosis
D.Loading should be initiated with 0.5mg/day
E.Effect is ameliorated by metronidazole via a bactericidal effect
658.Most β blockers
A.Have half lives 3-10 h
B.Have a small volume of distribution
C.Have poor oral bioavailability
D.Are highly lipid soluble and hence cross the BBB
E.Are rarely excreted unchanged
659.dobutamine
A.has no arrhythmogenic effect
B.decreases myocardial oxygen consumption
C.is a non selective β agonist
D.predominantly affects D2receptors in the CNS
E.may be used in heart failure
660.Which of the following act on the vasomotor centre
A.Prazosin
B.Methyldopa
C.Hydralazine
D.Reserpine
E.losartan