991.Examples of protein binding interaction
A.Aspirin –tolbutamide
B.Digoxin –chlorthiazide
C.Morphine –chlorpromazine

992.Quantal dose-response curves are
A.Used for determining the therapeutic index of a drug
B.Used for determining the maximal efficacy of a drug
C.Invalid in the presence of inhibitors of the drug being studied
D.Obtainable from the study of intact subjects but not from isolated tissue
E.Used to determine the statistical variation of the maximal response to the drug

993.2 drugs, A and B have the same mechanism of action. Drug A in dose of 5mg produces the same magnitude of effect as Drug B at 500mg
A.Drug B is less efficacious
B.Drug A is 100 times more potent
C.Toxicity of Drug A is less
D.Drug A is a better drug if maximal efficacy is needed
E.Drug A will have a shorter duration of action, because less is present

994.Biotransformation usually results in a product which is
A.more likely to be distributed intracellularly
B.less lipid soluble than the original
C.more likely to be reabsorbed by kidney tubules
D.more lipid soluble than the original drug
E.more likely to produce adverse effects

995.Induction of drug metabolism
A.Results in increased smooth ER
B.Results in increasedrough ER
C.Results in decreased enzymes in the soluble cytoplasmic fraction
D.Requires 3 –4 months to reach completion
E.Is irreversible

996.All of the following are mechanisms of drug permeation except
A.Aqueous diffusion
B.Aqueous hydrolysis
C.Lipid diffusion
D.Pinocytosis or endocytosis
E.Special carrier transport

997.Promethazine OD is taken, it is a weak base with pKa = 9.1
A.Urinary excretion would be accelerated by administering NH4Cl
B.Urinary excretion would be accelerated by giving NaHCO3
C.More of the drug would be ionized at the blood pH than the stomach pH
D.Absorption of the drug would be faster from the stomach than from the SI
E.Haemodialysis is the only effective therapy in OD

998.Aspirinis a weak organic acid, pKa = 3.5. What percentage of the given dose will be in the lipid soluble form at a stomach pH of 2.5

999. Pharmacokinetics is:
A. The study of biological and therapeutic effects of drugs
B. The study of absorption, distribution, metabolism and excretion of drugs
C. The study of mechanisms of drug action
D.The study of methods of new drug development

1000. What does “pharmacokinetics” include?
A. Complications of drug therapy
B. Drug biotransformation in the organism
C. Influence of drugs on metabolism processes
D. Influence of drugs on genes