751.Regarding gastrointestinal drugs, which is false
A.Cimetidine slows hepatic microsomal metabolism of warfarin and phenytoin
B.Omeprazole is capable of inhibiting 100% gastric acid secretion
C.Metoclopramide hastens gastric emptying and raises lower oesophageal sphincter pressure
D.Lactulose is an osmotic laxative
E.Sucrulfate is considered a colloidal bismuth compound
752.Cisapride
A.slows gastric empyting
B.delays oesophageal clearance
C.raises lower oesophageal sphincter pressure
D.increases pancreatic secretions
E.increases gastric secretions
753.Regarding H2receptor antagonists
A.They act via a final common pathway of H/K ATP ase
B.Famotidine is more potent than ranitidine
C.Cimetidine slows hepatic microsomal metabolism
D.They have all been associated with reversible gynaecomastia
E.All of the above are true
754.All of the following have an anti-emetic action except
A.Dexamethasone
B.Diazepam
C.Hydroxyzine
D.THC
E.Sulphalazine
755.Aluminium hydroxide
A.Causes milk alkali syndrome
B.May cause high PO4
C.Is contraindicated in renal failure
D.Is associated with constipation
E.Has been shown to effectively head gastric ulcers
756.Regarding methylxanthines
A.they reduce intracellular cAMP levels
B.they are adenosine agonists
C.they stimulate the enzyme phophodiesterase
D.they have direct positive chronotropic and inotropic effects on the heart
E.they are potent diuretics
757.Which is false with respect to theophylline
A.Oral bioavailability ~98%
B.Changes in intermittent dosing results in a new steady state within 1-2 days
C.It is mainly eliminated unchanged in the urine
D.Its VoD is ~ 0.5L/kg ideal body weight
E.IV boluses may cause convulsions or cardiac arrhythmias
758.Which does not reduce theophylline clearance
A.Phenytoin
B.Ethanol
C.Cimetidine
D.Erythromycin
E.Allopurinol
759.With regard to oral anti-asthma drugs
A.Prednisone is a long acting glucocorticoid
B.MTX has been shown to be beneficial in prednisone –dependent asthmatics in all studies
C.Cyclosporins toxicity limits its use as an oral anti-asthma agent
D.Nifedipine significantly inhibits exercise induced bronchoconstriction
E.Macrolides show no benefit in managing asthmatics
760.All of the following cause direct Bronchodilation except
A.atropine
B.adrenaline
C.salbutamol
D.theophylline
E.disodium chromoglycate