731.The major rate limiting enzyme step in the metabolism of ethyl alcohol is
A.Peroxisomal Catalase
B.P-450 oxidases
C.Acetaldehyde dehydrogenase
D.NAD reductase
E.Alcohol dehydrogenase

732.Which of the following features of chronic alcoholism is not due to the direct effect of ethanol toxicity to cells
A.Fatty change in liver
B.Cardiomyopathy
C.Peripheral neuropath

733.Wernicke’s encephalopathy is
A.Coma, ophthalmoplegia and areflexia
B.Confusion, ophthalmoplegia and ataxia
C.Nystagmus, areflexia and ophthalmoplegia
D.Nystagmus, hyperreflexia and ataxia
E.A contraindication to IV dextrose

734.Cannabinoids
A.produce tachycardias
B.have an antipsychotic action
C.act at a number of nonspecific receptors
D.constricts the pupil
E.all of the above

735.The following are safely used in pregnancy
A.Carbamazepine
B.Digoxin
C.Streptomycin
D.MTX
E.PTU

736.Which is safest to give in pregnancy
A.heparin
B.lithium
C.phenytoin
D.ACE inhibitors
E.Gentamicin

737.Regarding drugs in the elderly
A.The dose of lithium should be increased
B.Their phase II biotransformation is much poorer
C.They have increased lean body mass
D.They have higher serumalbumin
E.S/E are proportional to the amount of medication

738.Elderly patients
A.respond better to diuretics and β blockers than to ACE inhibitors as anti hypertensive treatment
B.have increase lean body mass
C.all have an age related decline in creatinine clearance
D.have increased serum albumin and α acid glycoprotein
E.are less sensitive torespiratory effects of opioid analgesics

739.In regards to drugs in pregnancy
A.Transfer of drugs across the placenta is independent of its lipid solubility and charge
B.Foetal proteins have a high binding affinity for drugs
C.Pregnant women have a smaller volumeof distribution
D.Gastric emptying time is shortened in the first day of life
E.A single intrauterine exposure to a drug can be teratogenic

740.Differences in the pharmacokinetics may occur in neonates because
A.They have a higher glomerular filtration rate in adults
B.Their liver enzyme systems are more active in adults
C.All their renal mechanisms (filtration, secretion and reabsorption) are decreased compared to adults
D.They have higher gastric acidity and decreased gastric emptying time than adults
E.None of the above

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