921.1stpass effect can be avoided by all of the following except
A.sublingual tablets
B.transdermal patch
C.IV administration
D.Rectal suppositories
E.None of the above

922.Maintenance dose depends on all except
A.Clearance
B.Target concentration
C.Oral bioavailability
D.Dosing interval
E.VoD

923.The VoD is apparently smaller when there is
A.Binding to tissues
B.Binding to plasma proteins
C.Ascites
D.Obesity
E.Pleural effusion

924.Clearance depends on all except
A.Dose
B.Blood flow
C.Function of liver
D.VoD
E.Function of kidneys

925.The rate limiting step in drug oxidation is
A.cP450 heme reduction
B.cP450 oxidation
C.flaviprotein reduction
D.flaviprotein oxidation
E.formation of NADPH

926.Phase I reactions producing polar metabolites –include all except
A.Oxidation
B.Reduction
C.Hydrolysis
D.Deanimation
E.Acetylation

927.Phase II reactions include all except
A.Glucuronidation
B.Glutathione conjugation
C.Sulfate conjugation
D.Methylation
E.Epoxidation

928.The following are enzyme inducers except
A.Chloramphenicol
B.Isoniazid
C.Ethanol
D.Steroids
E.Phenobarbital

929.The following areenzyme inhibitors except
A.Cimetidine
B.Ketoconazole
C.Isoniazid
D.Chloramphenicol
E.Erythromycin

930.The majority of drugs are metabolized by cP450
A.3A4
B.1A2
C.2AG
D.2C19
E.2E1

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