591.With regard to antivirals
A.Delvindine is a nucleoside reverse transcriptase inhibitor (NRTI)
B.Zidovudine (AZT) is a non-nucleoside reverse transcriptase inhibitor (NNRTI)
C.NRTIs activate HIV-1 reverse transcriptase
D.NRTIs require intracytoplasmic activation to the triphosphate form
E.Abacavir is a protease inhibitor

592.Flucloxacillin
A.Is not effective against Strep
B.Is active against enterococci and anaerobes
C.Blocks transpeptidation and inhibits peptidoglycan synthesis
D.Is poorly absorbed orally
E.Has excellent penetration into CNS and prostate

593.Cephalosporins
A.Are less stable than penicillins
B.Are active against enterococci and Listeria monocytogenes
C.Intrinsic antimicrobial activity is high
D.1stgeneration hasbetter activity against G+ve
E.Are active against methicillin resistant strains of Staph

594.The following require dosage adjustment in renal failure except
A.penicillin G
B.amoxycillin
C.nafcillin
D.piperacillin
E.ticarcillin

595.The IV drug of choice for diverticulitis is
A.Cefazolin
B.Cefuroxime
C.Cefoxitin
D.Ceftriaxone
E.Amoxicillin

596.Ceftriaxone is least effective for which infection
A.penicillin resistant Pneumococcal meningitis
B.Meningococcal meningitis
C.H. influenzae meningitis
D.Penicillin resistant gonococcus
E.Listeria monocytogenes meningitis

597.The mechanism of resistance most important with tetracyclines is
A.Efflux pump
B.β-lactamases
C.change in ribosomal proteins
D.impaired penetration
E.enzyme inactivation

598.Chlamydia in children is best treated with
A.Ceftriaxone
B.Chloramphenicol
C.Doxycycline
D.Erythromycin
E.Tetracycline

599.Drug that is most vestibulotoxic
A.Tobramycin
B.Gentamicin
C.Neomycin
D.Kanamycin
E.Amikacin

600.Which is the least appropriate for Rickettsia infection
A.Chloramphenicol
B.Tetracycline
C.Sulphamethoxazole
D.Erythromycin
E.Doxycycline

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