1661. The end of purine catabolism in man is :

A. Inosine
B. Hypoxanthine
C. Xanhine
D. Uric acid *
E. Urea

1662. DNA Fragments are sealed by :

A. DNA polymerase II
B. DNA Ligase *
C. DNA Gyrase
D. DNA Topoisomerase II
E. None of the above

1663. Hypouricemia can occur in :

A. Deficiency of ribonucleotide reductase
B. G-6 Phosphate deficiency
C. HGPRT Deficiency
D. Leukaemia
E. Xanthine oxidase deficiency *

1664. Lesch-Nyhan syndrome is due to deficiency of :

A. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) *
B. Phosphoribosyl pyrophosphate (PRPP)
C. Carbamoyl phosphate
D. Xanthine oxidase
E. Arginase

1665. Purine catabolism in humans results in:

A. Hypoxanthine
B. Urea
C. Uric acid *
D. Inosine
E. Xanthine

1666. In man chief catabolic product of pyrimidines is :

A. Beta-Alanine *
B. Allantion
C. Hypoxanthine
D. Urea
E. Uric acid

1667. The pyrimidine ring’s two nitrogen are provided by:

A. Ammonia and glycine
B. Aspirate and carbamoyl phosphate
C. Glutamine and ammonia
D. Aspartate and ammonia *
E. Aspartate and glycine

1668. Which of the following amino acids contributes both carbons and nitrogen atoms for purine synthesis ?

A. Glutamine
B. Glycine *
C. Glutamate
D. Cysteine
E. Lysine

1669. The initiation site of transcription is recognized by :

A. Alpha subunit of DNA dependent RNA Polymerase
B. Beta subunit of DNA dependent RNA Polymerase
C. Sigma factor*
D. RHO factor
E. None of the above

1670. Non coding sequences in a gene are known as :

A. Anticodons
B. Cistrons
C. Exons
D. Introns *
E. None sense codons