1651. Direction of DNA Synthesis is :

A. 5′—3′ *
B. 3′—5′
C. 5′—2′
D. 2′—5′
E. None of the above

1652. Synthesis of AMP from IMP requires the following :

A. GTP, Aspartic acid *
B. ATP, NAD, glutamine
C. Glutamine ATP
D. Glutamine NAD
E. None of the above

1653. The following amino acids take part in the synthesis of purines :

A. Glutamine, Asparate, Glycine *
B. Glycine, Asparte, Methionine
C. Glutamine Aspargine
D. Glutamine, Glycine
E. Glutamine, Asparate .Methionine

1654. The mRNA strand that would be transcribed from the DNA base sequence TCAGC IS :

A. UGACU
B. AGTCG *
C. GACUG
D. GACTG
E. GACGU

1655. Which of the following enzyme is inhibited by glutamine analogues :

A. Amido transferase *
B. Folate reductase
C. Phosphoribosyl
D. Hypoxanthine
E. Adenine phosphoribosyl

1656. In the synthesis of purine bases the amino acid that provides both carbon and nitrogen is :

A. Aspartate
B. Fumarate
C. Glutamate
D. Glycine *
E. Methionine

1657. All of the following compounds directly provide carbon and nitrogen atoms to form purine ring except :

A. Aspartate
B. Carbamoyl phosphate *
C. CO2
D. Glutamine
E. Glycine

1658. In a patient deficient in endonuclease , which of the following function is compromised :

A. Removal of introns
B. Removal of pyrimidine dimmers
C. Protection against DNA viruses
D. Misaligned base repair during DNA replication
E. Repair of mismatched bases during transcription

1659. A 20 Year old anemic man is found to have an abnormal form of ( 3 globin Hemoglobin constant spring ) that is 172 amino acids long, rather than the 141 found in the normal protein which of the following point mutation is consistent with this abnormality :

A. DAA > CAA *
B. UAA > UAG
C. CGA > UGA
D. GAU > GAC
E. GCA > GAA

1660. A deficiency of which of the following enzyme best explains a patient with lack of muscular coordination, urinary tract stones and compulsive urge to bite his fingers and lips :

A. Adenine phosphoribosyl transferase
B. Adenine deaminase
C. Hypoxanthine guanine phosphoribosyl transferase *
D. Orotate decarboxylase
E. Phenyl hydroxylase