861.Regarding serum markers in hepatitis
A.IgM in HAV provides life long immunity
B.In HBV, HBeAg, HBV DNA and DNA polymerase appear before HBsAg
C.Carrier state in HBV is defined by the presence of HBsAg in serum for 6/12 or longer after initial detection
D.Anti HBe indicate active viral replication
E.In HEV, serum transaminase precede elevation of IgM anti HEV
862.Conjugated hyperbilirubinaemia
A.Occurs when greater than 80% of bilirubin is conjugated
B.Is a feature of Gilbert’s
C.Is rarely associated with cholestasis
D.Is often seen in β thalassaemia
E.Is often associated with a clinical picture of jaundice, pruritis and xanthomata
863.The following are true for cirrhosis except
A.It is among the top 10 leading causes of death in the western world
B.The central pathogenic process is progressive fibrosis
C.It may be clinically silent
D.Alcoholic liver disease is the aetiology in 30% cases
E.Collagen type I and III are deposited in all parts of the lobule
864.Ascites
A.is due to lymphatic obstruction
B.involves percolation of hepatic lymph into the peritoneal cavity
C.does not involve renal retention of sodium and water
D.involves increased vascular permeability
E.is not associated with hepatic sinusoidal hypertension
865.Hepatitis C virus
A.Is a DNA virus
B.Has core antigens as serum markers
C.Is the ‘kissing disease’
D.Persistent infection and chronic hepatitis are the hallmarks
E.Has a low rate of cirrhosis
866.Which of the following indicates immunity to Hepatitis B virus
A.RNA polymerase
B.IgM anti-HBc
C.Anti-HBs
D.HBeAg
E.HBV-DNA
867.Unconjugated bilirubinaemia
A.Is soluble in aqueous solution
B.Is not protein bound
C.When present in excess is readily excreted in urine
D.Can cause kernicterus if present in excess in neonates
E.Is the major form of bilirubin elevated in gallstone obstruction
868.Hepatitis B virus
A.Is an unenveloped particle
B.Is an RNA virus
C.Is a member of the hepadnaviridae family
D.Results in chronic hepatitis in 30% acute infections
E.Has an incubation period of 2-6 weeks
869.regarding cirrhosis
A.30% caused by viral hepatitis
B.type I and III collagen are deposited in all portions of the lobule
C.the central pathogenesis is progressive nodule formation
D.Ito cells are considered as a minor source of collagen excess
E.Chronic inflammation has no role in its pathogenesis
870.Hep C infection
A.Is associated with sexual contact
B.Carries a 40% risk of cirrhosis
C.Isidiopathic in 10% cases
D.Carries a >50% risk of chronic progressive hepatitis