721. Malignant tumors has the following characteristics:
A. All malignant tumors are poorly differentiated
B. All malignant tumors metastasize
C. Anaplasia is a consequence of de-differentiation
D. Malignant tumors may develop capsules
E. Malignant tumors are always more rapidly proliferative than benign tumors

722. Dysplastic tissue:
A. has architectural anarchy
B. has nuclear & cytoplasmic pleomorphism
C. has more mitotic figures than are normally present
D. dysplastic changes may be reversible
E. all of the above are true

723. Which of the following skin tumor does NOT metastasize?
A. Squamous cell carcinoma
B. Basal cell carcinoma
C. Melanoma
D. All of the above can metastasize
E. None of the above metastasize

724. Normal nuclear: cytoplasmic ratio is:
A. 1:1
B. 1:2
C. 1:3
D. 1:4
E. none of the above

725. Which of the following tumors does NOT cause lytic lesions in the vertebrae?
A. prostatic carcinoma
B. renal cell carcinoma
C. colonic carcinoma
D. bronchogenic carcinoma
E. malignant melanoma

726. Which of the following tumor do NOT metastasize to bone?
A. breast carcinoma
B. prostatic carcinoma
C. glioma
D. bronchogenic carcinoma
E. renal cell carcinoma

727. Which of the following statements regarding tumorigenesis is TRUE?
A. All malignant tumors are monoclonal.
B. Mutant alleles of proto-oncogenes can incur cell transformation even in presence of their normal counter parts (ie. It is a dominant phenomenon)
C. Both mutant alleles of anti-oncogenes must exist for cell transformation to occur (ie. It is a recessive phenomenon)
D. Phenotypic attributes of a tumor is acquired in a stepwise fashion
E. All of the above

728. Which of the following statement is FALSE?
A. Oncoproteins targets the normal cellular proliferation pathway to induce tumor progression
B. 30% of all human tumor contain the ras oncoprotein
C. Oncoprotein production is not dependent on the availability of growth factors
D. Proto-oncogenes are regulatory segments in the DNA for c-oncogenes
E. No single oncogene can fully transform cells on its own

729. Maximum size of tumor compatible with life has:
A. 106 cells
B. 109 cells
C. 1012 cells
D. 1015 cells
E. 1018 cells

730. Neoplastic growth has the following characteristics:
A. All cells in a tumor is in actively replicating phase of the cell cycle as there is a loss of proliferative control.
B. Tumors with small growth fraction is refractive to chemotherapy
C. Tumor growth is associated with shortened cell cycle
D. Frequency of mitoses in a neoplasm is not reflective of its growth rate
E. All of the above are correct.

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