591. Hepatitis C:
A. Accounts for -50% transfusion-associated hepatitis.
B. Has a low rate of progression to chronic disease.
C. Stimulates the production of anti-HCV IgG which subsequently confers effective immunity.
D. Frequently develops into fulminant hepatitis after the initial acute infection.
E. Characteristically causes episodic elevations in serum transaminases with intervening near normal periods in chronic infections.

592. With regard to Hepatitis B infection, which of the following statements is FALSE?
A. Infected hepatocytes are capable of synthesizing and secreting large quantaties of non­infective surface protein
B. HBsAg appears before the onset of symptoms and peaks during overt disease.
C. HBeAg signifies active viral replication.
D. IgM anti HBc becomes detectable in serum shortly after the onset of symptoms, concurrent with the onset of elevated transaminases.
E. IgG anti HBs does not rise until after acute disease is over and sometime after the disappearance of HbsAg

593. Causes of unconjugated hyperbilirubinemia include:
A. Cholelithiasis
B. Oral contraceptive pill
C. Gilbert’s syndrome
D. Primary biliary cirrhosis
E. Rotor’s syndrome

594. Jaundice becomes clinically evident with serum bilirubin level above:
A. 0.5-1.0 mg/dL
B. 1.0-1.5 mg/dL
C. 1.5-2.0 mg/dL
D. 2.0-2.5 mg/dL
E. All of the above

595. Conjugated bilirubin is:
A. toxic to neonatal brain
B. is not bound to serum albumin
C. is insoluble in aqueous solution
D. is not filtered at the kidney
E. All of the above

596. The following tissue has yellow-green discoloration in jaundice EXCEPT:
A. skin
B. brain
C. liver
D. kidney
E. heart

597. Which is the least common cause of viral hepatitis?
A. hepatitis B
B. hepatitis E
C. Epstein barr virus
D. Cytomegalovirus
E. Adenovirus

598. Which of the following is a DNA virus?
A. Hepatitis A virus
B. Hepatitis B virus
C. Hepatitis C virus
D. Hepatitis D virus
E. Hepatitis E virus 

599. Hepatitis B is:
A. causes by picornavirus
B. spread by fecal-oral route
C. has incubation period of 30-180 days
D. > 50% develops chronic hepatitis
E. fulminant hepatits occurs in up to 10% cases

600. Hepatitis viruses:
A. HA V does not cause fulminant hepatitis
B. HA V has longer incubation period than HCV
C. HCV is the leading cause of chronic hepatitis worldwide
D. HDV superinfection is more common than coinfection with HBV
E. Only HBV infection wi11lead to hepatocellular carcinoma