621. A performed mediator of inflammation is
A. Prostaglandin
B. Histamine
C. Leukotriene
D. Nitric oxide
E. Platelet activating factor

622. In normal haemostasis
A. Factor V inhibits thrombosis
B. Alpha 2 micro globulin is antithrombotic
C. PGh favours platelet aggregation
D. Platelet aggregation is inhibited by von Willebrand factor
E. Tissue plasminogen activator is responsible for prothrombotic events

623. Mononuclear phagocytes
A. Are the predominant cells in three day old wounds
B. Are common in liver, spleen and pancreas
C. Produce fibroblast growth factor
D. Secrete interferon Y
E. Have a half life of one day

624. Normal endothelial cells decrease platelet aggregation by secreting
A. Interleukin 1
B. von Willebrand factor
C. Prostacyclin
D. Factor V
E. Thromboplastin

625. Interleukin 1 causes
A. N eutropaenia
B. Decreased sleep
C. Decreased prostaglandin synthesis
D. Increased collagen synthesis
E. Decreased leukocyte adherence

626. Thrombosis is potentiated by all of the following except
A. von Wille brand factor deficiency
B. Protein S deficiency
C. Antithrombin III deficiency
D. Thrombotic thrombocytopenia
E. Acute leukaemia

627. Acute compensatory mechanisms in shock include all of the following except
A. Baroreceptor reflexes
B. Reverse stress-relaxation of vascular smooth muscle
C. The effects of increased aldosterone secretion
D. Activation of the renin-angiotensin system
E. The central nervous system ischaemic response

628. The following are primary mediators of type I hypersensitivity reactions except
A. Adenosine
B. Neutrophil chemotactic factor
C. Heparin
D. Platelet activating factor
E. Acid hydro lases

629. Malignant neoplasms
A. Are independent of hormonal influence
B. Are always composed of homogeneous cell lines
C. Arise from differentiated cells by a process of anaplasia
D. Display abnormal nuclei with pale nucleoli
E. Typically grow more rapidly than benign

630. Regarding metastasis
A. All carcinomas have the ability to metastasise
B. Highly invasive carcinomas rarely metastasise
C. Carcinomas typically spread via lymphatics compared with haematogenous spread
D. Tumour cells develop increased cohesiveness of their cell surface in the formation of cancer cell emboli
E. Cells involved in lymphatic dissemination release degradative enzymes

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