421. In diabetes mellitus, glycogen vacuoles can be seen in:
A. Hepatocytes
B. Pancreatic islet cells .
C. Myocardial cells
D. Proximal convoluted tubular epithelial cells
E. All of the above.

422. Which of the following statements is FALSE?
A. Carbon & coal dusts accumulates in the alveolar macrophages, resulting in anthracosis.
B. Lipofuscin is a telltale sign of free radical injury to cells.
C. Hemochromatosis represents systemic iron overload without liver or pancreatic damage.
D. Large accumulation of bilirubin occurs in liver in obstructive jaundice, forming bile lakes
E. None of the above

423. Causes of metastatic calcification includes:
A. Hyperparathyroidism
B. Hyperthyroidism
C. Addison’s disease
D. Leukaemia
E. All of the above

424. Transudation may occur due to the following EXCEPT:
A. Increased intravascular hydrostatic pressure.
B. Decreased intravascular oncotic pressure.
C. Lymphatic Obstruction
D. Inflammation
E. Renal salt & water retention.

425. Endothelial cells can be activated (ie. develop procoagulant properties) by:
A. Cytokines
B. Infection
C. Hemodynamic factors
D. Plasma constituents.
E. All of the above.

426. Normal endothelium synthesize the following substance to promote antithrombotic properties:
A. Thrombomodulin
B. Membrane bound heparin like molecule
C. Tissue plasminogen activator (tPA)
D. Prostacyc1ine
E. All of the above

427. Which of the following is NOT a stimuli for platelet aggregation in hemostasis?
A. PDGF (NO)
B. ADP
C. Thrombin
D. Thromboxane A2
E. All of the above.

428. The role of thrombin includes:
A. Stimulates platelet aggregation.
B. Catalyze conversion of fibrinogen to fibrin
C. Mitogenic for fibroblasts
D. Stimulates neutrophil & macrophage adhesion
E. All of the above.

429. Which of the following statements regarding the coagulation system is FALSE?
A. Intrinsic PW of coagulation cascade occur on the surface of activated platelets.
B. Calcium is indispensible in the coagulation cascade.
C. Both intrinsic & extrinsic pathways of coagulation converge onto the activation of Factor x.
D. Extrinsic pathway is activated when the platelets are activated.
E. None of the above.

430. Natural anticoagulants exist to prevent the whole vasculature from clotting during hemostasis. They include:
A. Antithrombin III
B. Tissue plasminogen activator (t P A)
C. Protein C
D. Urokinase plasminogen activator (uPA)
E. All of the above

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