641. Which of the following is TRUE?
A. Zona glomerulosa does not produce cortisol or sex hormones because it lacks 17a hydroxylase.
B. Adrenocortical cells has abundant amount of LDL receptors
C. ACTH binds to receptors at adrenocortical cells to stimulate increased cholesterol formation
D. 21 J3 hydroxylase deficiency causes virulization
E. All of the above

642. Circulating free cortisol level reduces in:
A. pregnancy
B. multiple myeloma
C. nephrosis
D. cirrhosis
E. none of the above

643. Which of the following is TRUE regarding corticosteroid?
A. Cortisone is synthesized in Zona fasciculata of adrenal gland
B. Corticosterone binds more avidly to corticosteroid binding globulin (CGB) than cortisol.
C. During stress, elevated circulating free cortisol levels is due to reduced hepatic metabolism
D. Corticosteroids are excreted completely by urinary route
E. All of the above

644. Which of the following is TRUE regarding androgens?
A. In male, 2/3 of urinary ketosteroid is from testicular origin.
B. Adrenal androgens only have 20% activity of testosterone.
C. Adrenal androgen production is controlled by pituitary gonadotrophin
D. Plasma adrenal androgen concentration is same in both male & female
E. All of the above

645 Glucocorticoid:
A. has end organ anti-insulin action (sparing heart & brain)
B. has permissive action on catecholamine induced pressor & bronchodilator response.
C. Acts to overall suppress T cell number & activity
D. Stimulates increased number of neutrophils, platelets & red cells in circulation
E. All of the above

646. In glucocorticoid excess (Cushing’s syndrome), the following metabolic changes occurs:
A. Hypoglycemia
B. Hypokalaemia
C. Hyponatraemia
D. Protein catabolism                                                              E. All of the above

647. High dose steroid exerts anti-inflammatory action by:
A. Stabilize lysosomal membrane
B. Inhibits histamine release
C. Inhibits fibroblastic action
D. Inhibits IL-l & inhibits arachidonic acid release from cell membrane, blocking systemic actions of bacterial toxins
E. All of the above

648. Which of the following stimulates glucocorticoid secretion?
B. Angiotensin II
C. Serotonin
E. All of the above

649. Which of the following regarding primary hyperaldosteronism is FALSE?
A. mildhypematraemia
B. hypokalaemia
C. alkalosis
D. oedema
E. hypertension

650. Which of the following regarding aldosterone is FALSE?
A. Opens amilorideinhibitable sodium channels in basolateral membrane of renal tubular epithelial cells
B. Increased number & activity of N aIK ATPase at the basolateral membrane of renal tubular epithelial cells.
C. Sodium retention occurs at a lag time of 1-2 days
D. Mineralocorticoid receptor binds cortisol with higher affinity than to aldosterone
E. Mineralocorticoid sensitive tissue contains 11 i3 hydroxysteroid dehydrogenase to metabolize glucocorticoid.

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